In Very Young Infants Severity of Acute Bronchiolitis Depends On Carried Viruses
Identifieur interne : 000921 ( France/Analysis ); précédent : 000920; suivant : 000922In Very Young Infants Severity of Acute Bronchiolitis Depends On Carried Viruses
Auteurs : Christophe Marguet [France] ; Marc Lubrano [France] ; Marie Gueudin [France] ; Pascal Le Roux [France] ; Antoine Deschildre [France] ; Chantal Forget [France] ; Laure Couderc [France] ; Daniel Siret [France] ; Marie-Dominique Donnou [France] ; Michael Bubenheim [France] ; Astrid Vabret [France] ; François Freymuth [France]Source :
- PLoS ONE [ 1932-6203 ] ; 2009.
Abstract
RT amplification reaction has revealed that various single viruses or viral co-infections caused acute bronchiolitis in infants, and RV appeared to have a growing involvement in early respiratory diseases. Because remaining controversial, the objective was to determine prospectively the respective role of RSV, RV, hMPV and co-infections on the severity of acute bronchiolitis in very young infants.
209 infants (median age: 2.4 months) were enrolled in a prospective study of infants <1 year old, hospitalized for a first episode of bronchiolitis during the winter epidemic season and with no high risk for severe disease. The severity was assessed by recording SaO2% at admission, a daily clinical score (scale 0–18), the duration of oxygen supplementation and the length of hospitalization. Viruses were identified in 94.7% by RT amplification reaction: RSV only (45.8%), RV only (7.2%), hMPV only (3.8%), dual RSV/RV (14.3%), and other virus only (2%) or coinfections (9%). RV compared respectively with RSV and dual RSV/RV infection caused a significant less severe disease with a lower clinical score (5[3.2–6] vs. 6[4–8], p = 0.01 and 5.5[5–7], p = 0.04), a shorter time in oxygen supplementation (0[0–1] days vs. 2[0–3] days, p = 0.02 and 2[0–3] days, p = 0.03) and a shorter hospital stay (3[3–4.7] days vs.6 [5–8] days, p = 0.001 and 5[4–6] days, p = 0.04). Conversely, RSV infants had also longer duration of hospitalization in comparison with RSV/RV (p = 0.01) and hMPV (p = 0.04). The multivariate analyses showed that the type of virus carried was independently associated with the duration of hospitalization.
This study underlined the role of RV in early respiratory diseases, as frequently carried by young infants with a first acute bronchiolitis. RSV caused the more severe disease and conversely RV the lesser severity. No additional effect of dual RSV/RV infection was observed on the severity.
Url:
DOI: 10.1371/journal.pone.0004596
PubMed: 19240806
PubMed Central: 2644758
Affiliations:
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PMC:2644758Le document en format XML
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<author><name sortKey="Bubenheim, Michael" sort="Bubenheim, Michael" uniqKey="Bubenheim M" first="Michael" last="Bubenheim">Michael Bubenheim</name>
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<author><name sortKey="Vabret, Astrid" sort="Vabret, Astrid" uniqKey="Vabret A" first="Astrid" last="Vabret">Astrid Vabret</name>
<affiliation wicri:level="1"><nlm:aff id="aff9"><addr-line>Laboratory of Human and Molecular Virology, Caen University Hospital Clemenceau, Caen, France</addr-line>
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<author><name sortKey="Freymuth, Francois" sort="Freymuth, Francois" uniqKey="Freymuth F" first="François" last="Freymuth">François Freymuth</name>
<affiliation wicri:level="1"><nlm:aff id="aff9"><addr-line>Laboratory of Human and Molecular Virology, Caen University Hospital Clemenceau, Caen, France</addr-line>
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<country xml:lang="fr">France</country>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>RT amplification reaction has revealed that various single viruses or viral co-infections caused acute bronchiolitis in infants, and RV appeared to have a growing involvement in early respiratory diseases. Because remaining controversial, the objective was to determine prospectively the respective role of RSV, RV, hMPV and co-infections on the severity of acute bronchiolitis in very young infants.</p>
</sec>
<sec><title>Methods and Principal Findings</title>
<p>209 infants (median age: 2.4 months) were enrolled in a prospective study of infants <1 year old, hospitalized for a first episode of bronchiolitis during the winter epidemic season and with no high risk for severe disease. The severity was assessed by recording SaO<sub>2</sub>
% at admission, a daily clinical score (scale 0–18), the duration of oxygen supplementation and the length of hospitalization. Viruses were identified in 94.7% by RT amplification reaction: RSV only (45.8%), RV only (7.2%), hMPV only (3.8%), dual RSV/RV (14.3%), and other virus only (2%) or coinfections (9%). RV compared respectively with RSV and dual RSV/RV infection caused a significant less severe disease with a lower clinical score (5[3.2–6] vs. 6[4–8], p = 0.01 and 5.5[5–7], p = 0.04), a shorter time in oxygen supplementation (0[0–1] days vs. 2[0–3] days, p = 0.02 and 2[0–3] days, p = 0.03) and a shorter hospital stay (3[3–4.7] days vs.6 [5–8] days, p = 0.001 and 5[4–6] days, p = 0.04). Conversely, RSV infants had also longer duration of hospitalization in comparison with RSV/RV (p = 0.01) and hMPV (p = 0.04). The multivariate analyses showed that the type of virus carried was independently associated with the duration of hospitalization.</p>
</sec>
<sec><title>Conclusion</title>
<p>This study underlined the role of RV in early respiratory diseases, as frequently carried by young infants with a first acute bronchiolitis. RSV caused the more severe disease and conversely RV the lesser severity. No additional effect of dual RSV/RV infection was observed on the severity.</p>
</sec>
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